Famous film director Guido Contini struggles to find harmony in his professional and personal lives, as he engages in dramatic relationships with his wife, his mistress, his muse, his agent, and his mother.

A Rome policewoman teams up with a British Interpol agent to find a crafty serial killer who plays a taunting game of cat-and-mouse with the police by abducting and killing young women and showing it over an Internet web cam.